https://sabitagenious.blogspot.com/2018/08/sickle-cell-anemia-is-due-to-altered.html
Sickle cell anemia is due to altered hemoglobin
The first human disease occurs due to the mutation in a cell protein was sickle cell anemia. It is caused by a defect in the hemoglobin (oxygen carrier molecule), which leads to impaired oxygen delivery to tissues.
Symptoms and features in patients of Sickle cell anemia
The major symptoms of sickle cell anemia are the direct result of the abnormally shaped sickle red blood cells blocking the flow of hemoglobin/blood. Certain organs are prone to minor oxygen levels, such as when hemoglobin moves slowly through high metabolism rates like the brain, muscles, and the placenta in a pregnant woman with sickle cell anemia also the other diseases such spleen, liver, lungs, heart, eye damage, swelling and inflammation of hand, feet, arthritis and kidney. These conditions make these cells, tissues, and organs predisposed to damage from sickle cell anemia.
Diagnosis of sickle cell disease patients
Before birth (Prenatal diagnosis) of sickle cell anemia is probably using amniocentesis technique. The sample obtained is then tested for a DNA study of the fetal cells. The hemoglobin electrophoresis tests accurately identify the hemoglobin’s in the blood by separating them. The separation of the dissimilar hemoglobin’s is potential because of the distinctive electrical charges they each have on their protein surfaces, causing them each to move normally in an electrical field as tested in the laboratory.
Finally, genetic counseling can be helpful for parents and families to avoid sickle cell anemia. Sickle cell anemia is the hereditary disease. The parents and families must be carriers of the sickle cell gene for a child to be affected with sickle cell anemia. If each parent is a carrier, any child has one chance in two (50%) of also being a carrier and a one in four (25%) chance of inheriting both genes from the parents and being affected with sickle cell anemia.
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| Sickle cells |
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